Fisk & Co. Apothecaries was located at 41 Main Street, which was situated in the Lee's Block, in Pawtucket. Frank D. Fisk, the owner, had bought out his partner in Fisk & Coe in 1872 , and along with his new partner, Stephen F. Fisk, began the manufacturing of their Syrup of Sarsaparilla, which claimed to be a blood purifier.

By 1878, Stephen had taken over the entire operation and had moved it to 129 Main Street. (He also became manager of the Pawtucket Music Hall around the same time.)

Stephen ran the company until his retirement in 1910 and he passed away two years after. The company later became the Fisk Drug Company under unknown management.