Dr. Charles Morse, Jr. started manufacturing his Compound of Yellow Dock Root in 1850 in Providence at 102 and 66 Fountain Street. In 1852 the company became Morse & Co. with Charles H. Morse (son? brother?) as partner. By 1860 Charles H. had left and was on his own at the rear of 11 Broadway manufacturing his own syrups. In the interim, Charles Morse Jr. became associated with the Rhode Island Medicine Company at 348 Westminister Street where he remained until about 1883. He may have started a new company because a Morse Yellow Dock Root Syrup Company is listed as a laboratory at 153-157 Dyer Street in Providence from 1883-1887.

The Compound of Yellow Dock Root, Morse's "Celebrated Syrup", was used for regulating the liver and digestive organs and also for purifying the blood. It was a cure for dyspepsia, indigestion, constipation, headache, humor, and salt rheum.